Scientific Interests: Dr. Virendra Singh presently working as an Assistant Professor, School of Biotechnology, JNU, New Delhi, has expertise in the area of Cancer Genomics. Previously, Dr. Singh has also been associated with Maulana Azad Medical College, New Delhi, as Scientist-II in the Multidisciplinary Research Unit (MRU). He did his doctoral research from CSIR-Indian Institute of Toxicology Research, Lucknow and had also been associated with ICMR-National Institute of Pathology, New Delhi for his postdoctoral research before joining Prof. Rana P. Singh’s laboratory as UGC-Kothari Postdoctoral Fellow.

Scientific Interests: I am interested in research at the interface of Cancer Biology and Genomics, especially the discovery of role of vitamin D in Bladder cancer stem cells. I am working on project entitled - Study of inhibitory effects of calcitriol (1α,25 dihydroxyvitamin D3) on bladder cancer stem cells and their mechanism of its action. My research is focused to establish the role of Calcitriol (Vitamin D3) on Bladder cancer stem like cells T24 and 5637 cells and effect on stemness, proliferation and wnt signaling pathway.

Scientific Interests: Dr. Abhijeet Mishra previously joined as Asst. Prof. at Department of Biomedical Science, Acharya Narendra Dev College, University of Delhi. He also worked under supervision of Prof Rana P. Singh as a UGC-Kothari Postdoctoral Fellow. His area of research dedicated towards biosynthesis of nanoparticles and their biomedical applications.

Scientific Interest: My research interest lies in deciphering the contribution of host stroma/immune system in cancer progression and treatment resistance in cancers. I am fascinated by how cancer cell actively alters the surrounding normal tissues to create a conducive environment to support its growth. The tumor-immune cell relationship is both complex and minimally understood. My research goals are focused on: A) Understanding the mechanisms that enable cancer cells to effectively evade immune response; B) Delineate the role of tumor-driven inflammation in tumor recurrence and metastatic progression; C) Studying tumor-immune crosstalk regulating radiotherapeutic resistance.

Study of mitochondrial fission/fusion dynamics and its role in colorectal cancer growth, survival, migration and angiogenesis in response to short chain fatty acid. M.Sc. in Biotechnology, Veer Narmad South Gujarat University, Surat. B.Sc. in Biotechnology, Veer Narmad South Gujarat University, Surat.

Scientific Interests: My research work focused on chemoprevention of liver cancer which involved examining the efficacy of novel phytochemicals using various pre-clinical models of liver cancer, and associated mechanisms of action, especially apoptosis, cell cycle, and cell signal- modulatory effects. Further, as a Research Associate, I explored the chemoprevention method of breast cancer and its association with miRNAs in both in vitro and in vivo models.

Scientific Interests: Currently, I am working on the in vitro and in vivo models for Bone metastasis and Cancer stem cells in Prof. Shivendra V Singh’s Lab at the University of Pittsburgh. I completed my Ph.D. in the year 2017 under the mentorship of Prof. Rana P. Singh, School of Life Sciences, Jawaharlal Nehru University, and worked on the anticancer effects of Diallyl trisulfide on the in vitro and in vivo models for head and neck cancer.

Scientific Interests: My research interest is to study the signal transduction pathways that modulate the growth, survival and development of therapeutic resistance in cancer cells; primarily focused on the receptor tyrosine kinases (RTKs)- and growth factor-mediated signaling pathways.

Scientific Interests: My current research interest is focused on cancer stem cells heterogeneous populations of cells present in tumor tissue contributing to cancer progression, metastasis, and drug resistance. Further, targeted therapy can be achieved following the use of phytochemicals and drugs that selectively affect cancer stem cells and improve tumor immunity. Also, I am working on role of small molecules in promoting or inhibiting the proliferation of different immune cells to target specific types of cancer cells.

Scientific Interests: My research interest in carcinogenesis includes cell cycle progression, apoptosis, cell survival signaling, organ specific carcinogenesis, drug resistance and associated mechanisms in various cancers. My prior interest is to explore the anticancer potential of plant extracts, small molecules (phytochemicals) and find their molecular mechanisms in both in vitro as well as in vivo systems by using latest techniques. Presently working as Project Research Fellow at School of Life Sciences, Jawaharlal Nehru University, New Delhi in a project funded by Ministry of AYUSH, Government of India, where I am exploring the anticancer activity and associated mechanisms of Ayurvedic and Unani formulations.

Scientific Interests: Cancer Biology, Glycobiology, Notch Signaling. Interested in identifying the mechanisms by which O-GlcNAc versus O- fucose glycans control ligand-induced Notch signaling in the development and homeostasis of the small intestine.

Scientific Interests: I am pursuing my post-doctoral research fellowship in Prof F Stephen Hodi’s laboratory at Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts. I completed my Ph.D. from Prof. Rana P. Singh’s laboratory in 2018 and worked on exploring the anti-metastatic effects of small molecule inhibitor Fisetin in non-small cell lung carcinoma using in vitro as well as in vivo models. My current research interests involve investigating the role of angiogenesis in immune regulation and homing plus establishing 3-D models for studying them. In addition, I am using high throughput screening methods to establish expression libraries from patient-derived endothelium. My research efforts are also directed at studying mechanisms of immunotherapy in advanced melanoma patients.

Scientific Interests: Completed my Ph.D. in Cancer Biology in 2019 from Jawaharlal Nehru University, India under the guidance of Prof. Rana P. Singh. The primary focus of my dissertation work was to understand the role of IGFBP-3 (Insulin-like Growth Factor Binding Protein-3), an essential component of the IGF system, on prostate cancer progression. Currently, I am studying the mechanism of treatment resistance in Head & Neck, and Triple negative breast cancer using chemical probes developed in Malhotra lab.

Scientific Interests: I have two main areas of interest. 1. Chemical Warfare Agent-Induced Toxicity 2. Cancer Biology. My current research focuses on the development of a comprehensive understanding of the vital signaling pathways and mechanism involved in chemical warfare agent-induced toxicity in different organs (ocular, skin, lungs, etc.) and its mitigation using natural and synthetic agents. My other area of research focuses on targeting cancer and its microenvironment and understanding the underlying mechanisms of cancer metabolism and metastasis. During my Ph.D., my research focused on elucidating the mechanism of action of cell death and restricting tumor growth in in-vitro models of breast cancer by dietary phytochemicals.

Scientific Interests: Currently working in a virology laboratory. Responsible for carrying out covid diagnostics, data compilation and reporting. Interested in cancer chemotherapeutics and indigenous medicinal plants with anticancer properties.

Scientific Interests: My research focuses on breast cancer treatment by using combination therapy strategy, finding new molecular pathways and development of novel cancer therapeutics. I am utilizing various genetic, biochemical, and genomic experimental approach. I am using ex vivo (cultured mammalian cells and using CRISPR-Cas9 technology) and in vivo (genetically modified mouse) models for the study.

Scientific Interests: Presently, I am working in the field of cancer immunology, where I am trying to explore the mechanisms involving the T-cell exhaustion after chronic infections or other long-term antigen exposures like Cancer.

Scientific Interests: My current research area is hematology. Here I am studying an anticoagulant protein named Protein S. Protein S is a vitamin K dependent natural anticoagulant glycoprotein, which deficiency leads to deep vein thrombosis (DVT) and arterial thrombosis. Role of protein S as a cofactor of activated protein C (APC) and binding partner of C4b binding protein (C4BP) are well established. Our lab is studying its new role as an independent anticoagulant activity like binding with factor iX and inhibiting its activity. We are also working on role of hypoxia and estrogen in protein S regulation. During my PhD, I explored the interactive network between PARP-1 and EMT in human cancer cells. In this study, I found PARP-1 (Poly ADP-ribose Polymerase) regulates EMT (epithelial to mesenchymal transition) via modulating different transcription factor like p65, ZEB1 and Smad4 in non-small cell lung carcinoma.

Scientific Interests: Effects of RCCS-induced microgravity on epigenetic alterations, cell viability, cell cycle regulation, apoptosis, DNA damage and repair in normal microglial, glioblastoma and promyelocytic leukemic cells.

Fellowship: UGC SRF Scientific Interests: DNA-repair activation is a major obstacle in the therapeutics resistance development. DNA repair pathways have been critical targets for chemotherapy drugs in clinical settings. Cancer cells deals with the DNA damage via activation of DNA repair mechanism. We are interested in exploring the mechanistic insights involved in evolved mechanisms in tumour cells to ensure rapid proliferation and survival of cancer cells.

Fellowship: DST INSPIRE Scientific Interests: Identification of contemporary approaches to establish the potential role of fisetin in targeting head and neck squamous cell carcinoma (HNSCC) bulk cells along with cancer stem cells to prevent relapse and regrowth of HNSCC.

Fellowship: UGC SRF Scientific Interests: My work aims to basically integrate mitochondrial biology and cancer. The work focusses mainly on colorectal cancer cell lines. Main objectives of my study include: i) Investigating mitochondrial transfer between cells and its consequences, including rescue of normal mitochondrial function after transfer of healthy mitochondria to cells induced with mitochondrial damage. ii) Mitochondrial dynamics including fission and fusion of mitochondria. iii) Role of healthy mitochondria in stemness of cancer cells will be further investigated.

Fellowship: UGC SRF Scientific Interests: To understand the regulatory mechanism of breast cancer cells via exploring the role of microRNAs and phytochemicals in cancer cell proliferation, migration, invasion, and apoptosis.

Fellowship: DBT JRF Scientific Interests: My research interest lies in the area of space and cancer biology. The primary focus of my work is on studying the alterations in molecular mechanisms under the exposure of two major space stress factors i.e. microgravity and radiation. We aim to elucidate the cellular and molecular changes which may be associated with the risk and progression of cancer to astronauts. My research is mainly focused on studying the effects of the space stress factor on DNA damage and repair pathways.

Fellowship: UGC JRF Scientific Interests: My research is mainly focused on delineating the mechanistic details of radioresistance in head and neck cancers focusing on DNA damage responses and cancer stem cells that ultimately lead to increased cell survival and radioresistance. We are trying explore the radiosensitizing effect of the small molecules on head and neck cancer cells targeting DNA repair pathways and stemness thereby modulating cell survival and radiation resistance and exploring the associated signaling targets with the ultimate goal of enhancing the therapeutic index.

Fellowship: CSIR JRF Scientific Interests: My research interest is to investigate the role of Long non-coding RNAs in Head and neck Squamous Cell Carcinoma (HNSCC) development and its modulation by phytochemicals. The study will possibly uncover the novel mechanisms of lncRNA in HNSCC and also help in evaluating the regulatory role of phytochemical via lncRNA for cancer prevention and treatment.

Fellowship: ICMR SRF Scientific Interests: My current research interest is based on investigating the effects of phytochemical on PD1, PD-L1 and CTLA-4 Immune Checkpoint Regulators in Head & Neck squamous cell Carcinoma (HNSCC). My study is focused on elucidating the mechanisms underlying drug resistance, Immune therapy, Immune Checkpoints.