Research Articles

Publications (2000 – 2015) [Scopus]

Summary - Total: 118(Research articles: 109; Book chapters: Book: 1)

Research Articles:

  1. Schlaepfer IR, Nambiar DK, Ramteke A, Kumar R, Dhar D, Agarwal C, Bergman B, Graner M, Maroni P, Singh RP, Agarwal R, Deep G. Hypoxia induces triglycerides accumulation in prostate cancer cells and extracellular vesicles supporting growth and invasiveness following reoxygenation. Oncotarget. 6(26), 22836-56, 2015.[PMID: 26087400]
  2. Prajapati V, Kale RK, Singh RP. Silibinin combination with arsenic strongly  inhibits survival and invasiveness of human prostate carcinoma cells. Nutr Cancer. 67(4), 647-58, 2015. [PMID: 25868784]
  3. Prajapati V, Kale RK, Singh RP. Silibinin combination with arsenic strongly  inhibits survival and invasiveness of human prostate carcinoma cells. Nutr Cancer. 67(4), 647-58, 2015. [PMID: 25868784]
  4. Nambiar DK, Rajamani P, Singh RP. Silibinin attenuates ionizing radiation-induced pro-angiogenic response and EMT in prostate cancer cells. Biochem Biophys Res Commun. 456(1), 262-8, 2015.[PMID: 25446081]
  5. Nambiar D, Deep G, Singh RP, Agarwal C, Agarwal R. Silibinin inhibit aberrant lipid metabolism, proliferation and emergence of androgen-independence in prostate cancer cells via primarily targeting the sterol response element binding protein 1. Oncotarget, 5, 2014.[PMID: 25294820]
  6. Tailor D, Hahm ER, Kale RK, Singh SV, Singh RP. Sodium butyrate induces DRP1-mediated mitochondrial fusion and apoptosis in human colorectal cancer cells. Mitochondrion, 16, 55-64, 2014.[PMID: 24177748]         
  7. Jhala DV, Kale RK, Singh RP. Microgravity alters cancer growth and progression. Current Cancer Drug Targets, 14(4):394-406, 2014.[PMID: 24720362]
  8. Mittal A, Tabasum S, Singh RP. Berberine in combination with doxorubicin suppresses growth of murine melanoma B16F10 cells in culture and xenograft. Phytomedicine, 21, 340-47, 2014.[PMID: 24176840]
  9. Vundru SS, Kale RK, Singh RP. β-sitosterol induces G1 arrest and causes depolarization of mitochondrial membrane potential in breast carcinoma MDA-MB-231 cells. BMC Complement Alternative Medicine, 13(1):280, 2013.[PMID: 24160369]
  10. Agarwal R, Kale RK, Rao CV, Singh RP. Introduction to Special Issue on Molecular Basis for Cancer Prevention with Bioactive Food Components in Nutrition and Cancer--an International Journal. Nutrition and Cancer, 65 S1:1-2. 2013.[PMID: 23682777]
  11. Bhat TA, Nambiar D, Tailor D, Pal A, Agarwal R, Singh RP. Acacetin inhibits in vitro and in vivo angiogenesis and down-regulates Stat signaling and VEGF expression. Cancer Prevention Research, 6, 1128-39, 2013.[PMID: 23943785]
  12. Singh N, Nambiar D, Kale RK, Singh RP. Usnic Acid inhibits growth and induces cell cycle arrest and apoptosis in human lung carcinoma A549 cells. Nutrition and Cancer,65 (S1), 36-43, 2013.[PMID: 23682781]
  13. Nambiar D, Singh RP. Advances in prostate cancer chemoprevention: a translational perspective. Nutrition and Cancer, 65 (S1), 12-25, 2013.[PMID: 23682779]
  14. Nambiar D, Prajapati V, Agarwal R, Singh RP. In vitro and in vivo anticancer efficacy of silibinin against human pancreatic cancer BxPC-3 and PANC-1 cells. Cancer Letters, 2012 Sep 26. doi: pii: S0304-3835(12)00539-3.[PMID: 23022268]
  15. Bhat TA, Nambiar D, Pal A, Agarwal R, Singh RP. Fisetin inhibits various attributes of angiogenesis in vitro and in vivo: Implications for angioprevention. Carcinogenesis, 33; 385-93, 2012.[PMID: 22139440]
  16. Tyagi A, Agarwal C, Dwyer-Nield LD, Singh RP, Malkinson AM, Agarwal R. Silibinin modulates TNF-α and IFN-γ mediated signaling to regulate COX2 and iNOS expression in tumorigenic mouse lung epithelial LM2 cells. Molecular Carcinogenesis, 51, 832-42, 2012.[PMID: 21882257]
  17. Nambiar D, Rajamani P, Singh RP. Effects of phytochemicals on ionization radiation-mediated carcinogenesis and cancer therapy. Mutation Research Reviews, 728; 139-57, 2011.[PMID: 22030216]
  18. Kaur M, Tyagi A, Singh RP, Sclafani RA, Agarwal R, Agarwal C. Grape seed extract upregulates p21 (Cip1) through redox-mediated activation of ERK1/2 and post-transcriptional regulation leading to cell cycle arrest in colon carcinoma HT29 cells. Molecular Carcinogenesis, 50; 553-62, 2011.[PMID: 21268136]
  19. Ramasamy K, Dwyer-Nield LD, Serkova NJ, Hasebroock KM, Tyagi A, Raina K, Singh RP, Malkinson AM, Agarwal R. Silibinin prevents lung tumorigenesis in wild-type but not in iNOS-/- mice: potential of Real-Time Micro-CT in lung cancer chemoprevention studies. Clinical Cancer Research, 16; 753-61, 2011.[PMID: 21148748]
  20. Bhat TA, Moon JS, Lee S, Yim DS, Singh RP.  Inhibition of angiogenic attributes by decursin in endothelial cells and ex vivo rat aortic ring angiogenesis model. Ind. J. Experimental Biology, 49; 848-56, 2011.[PMID: 22126016]
  21. Prajapati V, Kale RK, Singh RP. Arsenic and its combinations in cancer therapeutics. Therapeutic Delivery, 2; 793-806, 2011.[PMID: 22822509]
  22. Ravichandran K, Velmurugan B, Gu M, Singh RP, Agarwal R. Inhibitory effect of silibinin against azoxymethane-induced colon tumorigenesis in A/J mice. Clinical Cancer Research, 16; 4595-606, 2010.[PMID: 20823143]
  23. Rajamanickam S, Velmurugan B, Kaur M, Singh RP, Agarwal R. Chemoprevention of intestinal tumorigenesis in APCmin/+ mice by silibinin. Cancer Research, 70; 2368-78, 2010.[PMID: 20215518]
  24. Velmurugan B, Singh RP, Agarwal R, Agarwal C. Dietary feeding of grape seed extract prevents azoxymethane-induced colonic aberrant crypt foci formation in Fischer 344 rats. Molecular Carcinogenesis, 49; 641-52, 2010.[PMID: 20564341]
  25. Kaur M, Velmurugan B, Tyagi A, Agarwal C, Singh RP, Agarwal R. Silibinin suppresses growth of human colorectal carcinoma SW480 cells in culture and xenograft through down-regulation of beta-catenin-dependent signaling. Neoplasia, 12; 415-24, 2010.[PMID: 20454513]
  26. Mateen S, Tyagi A, Agarwal C, Singh RP, Agarwal R. Silibinin inhibits human non-small cell lung cancer cell growth through cell-cycle arrest by modulating expression and function of key cell-cycle regulators. Molecular Carcinogenesis, 49; 247-58, 2010.[PMID: 19908243]
  27. Velmurugan B, Singh RP, Kaul N, Agarwal R, Agarwal C. Dietary feeding of grape seed extract prevents intestinal tumorigenesis in APCmin/+ mice. Neoplasia, 12; 95-102, 2010.[PMID: 20072658]
  28. Singh RP, Raina K, Deep G, Chan D, Agarwal R. Silibinin suppresses growth of human prostate carcinoma PC-3 orthotopic xenograft via activation of extracellular signal-regulated kinase 1/2 and inhibition of signal transducers and activators of transcription signaling. Clinical Cancer Research, 15; 613-21, 2009.[PMID: 19147767]
  29. Rajamanickam S, Kaur M, Velmurugan B, Singh RP, Agarwal R. Silibinin Suppresses Spontaneous Tumorigenesis in APC (min/+) Mouse Model by Modulating Beta-Catenin Pathway. Pharmaceutical Research, 26; 2558-67, 2009.[PMID: 19779968]
  30. Roy S, Gu M, Ramasamy K, Singh RP, Agarwal C, Siriwardana S, Sclafani RA, Agarwal R. p21/Cip1 and p27/Kip1 Are essential molecular targets of inositol hexaphosphate for its antitumor efficacy against prostate cancer. Cancer Research,69; 1166-73, 2009.[PMID: 19176374]
  31. Singh RP, Agarwal R. Cosmeceuticals and silibinin. Clinics in Dermatology, 27; 479-84, 2009.[PMID: 19695480]
  32. Tyagi A, Singh RP, Ramasamy K, Raina K, Redente EF, Dwyer-Nield LD, Radcliffe RA, Malkinson AM, Agarwal R. Growth inhibition and regression of lung tumors by silibinin: modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3. Cancer Prevention Research, 2; 74-83, 2009.[PMID: 19139021]
  33. Kang TJ, Lee SY, Singh RP, Agarwal R, Yim DS. Anti-tumor activity of oxypeucedanin from Ostericum koreanum against human prostate carcinoma DU145 cells. Acta Oncologica, 48; 895-900, 2009.[PMID: 19322700]
  34. Singh RP, Gu M, Agarwal R. Silibinin inhibits in vivo growth of colorectal cancer by inhibiting tumor cell proliferation and angiogenesis. Cancer Research, 68; 2034-50, 2008.[PMID: 18339887]
  35. Raina K, Rajamanickam S, Singh RP, Deep G, Chittezhath M, Agarwal R. Stage-specific inhibitory effects and associated mechanisms of silibinin on tumor progression and metastasis in transgenic adenocarcinoma of the mouse prostate model. Cancer Research, 68; 6822-30, 2008.[PMID: 18701508]
  36. Singh RP, Raina K, Sharma G, Agarwal R. Silibinin inhibits established prostate tumor growth, progression, invasion, and metastasis and suppresses tumor angiogenesis and epithelial-mesenchymal transition in transgenic adenocarcinoma of the mouse prostate model mice. Clinical Cancer Research, 14; 7773-80, 2008.[PMID: 19047104]
  37. Velmurugan B, Singh RP, Tyagi A, Agarwal R.Inhibition of azoxymethane-induced colonic aberrant crypt foci formation by silibinin in male Fisher 344 rats. Cancer Prevention Research, 1; 376-84, 2008.[PMID: 19138982]
  38. Deep G, Raina K, Singh RP, Oberlies NH, Kroll DJ, Agarwal R. Isosilibinin inhibits advanced human prostate cancer growth in athymic nude mice: Comparison with silymarin and silibinin. International Journal of Cancer, 123; 2750-8, 2008.[PMID: 18798272]
  39. Chittezhath M, Deep G, Singh RP, Agarwal C, Agarwal R. Silibinin inhibits cytokine-induced signaling cascades and down-regulates inducible nitric oxide synthase in human lung carcinoma A549 cells. Molecular Cancer Therapeutics, 7; 1817-26, 2008.[PMID: 18644994]
  40. Roy S, Singh RP, Agarwal C, Siriwardana S, Sclafani R, Agarwal R. Downregulation of both p21/Cip1 and p27/Kip1 produces a more aggressive prostate cancer phenotype. Cell Cycle, 12; 1828-35, 2008.[PMID: 18583941]
  41. Raina K, Rajamanickam S, Singh RP, Agarwal R. Chemopreventive efficacy of inositol hexaphosphate on prostate tumor growth and progression in TRAMP mice. Clinical Cancer Research, 14; 2177-84, 2008.[PMID: 18483386]
  42. Bhat TA, Singh RP. Tumor angiogenesis - A potential target in cancer chemoprevention. Food Chemical Toxicology, 46; 1334-45, 2008.[PMID: 17919802]
  43. Singh RP, Tyagi A, Sharma G, Mohan S, Agarwal R. Oral silibinin inhibits in vivo human bladder tumor xenograft growth involving down-regulation of survivin. Clinical Cancer Research, 14; 300-308, 2008.[PMID: 18172282]
  44. Tyagi A, Raina K, Singh RP, Gu M, Agarwal C, Harrison G, Glode LM, Agarwal R. Chemopreventive effects of silymarin and silibinin on N-butyl-N-(4-hydroxybutyl) nitrosamine induced urinary bladder carcinogenesis in male ICR mice. Molecular Cancer Therapeutics, 6; 3248-55, 2007.[PMID: 18089718]
  45. Singh RP, Deep G, Blouin MJ, Pollak MN, Agarwal R. Silibinin suppresses in vivo growth of human prostate carcinoma PC-3 tumor xenograft. Carcinogenesis, 28; 2567-74, 2007.[PMID: 17916909]
  46. Raina K, Blouin MJ, Singh RP, Majeed N, Deep G, Varghese L, Glodé LM, Greenberg NM, Hwang D, Cohen P, Pollak MN, Agarwal R. Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model. Cancer Research, 67; 11083-91, 2007.[PMID: 18006855]
  47. Raina K,* Singh RP,* Agarwal R, Agarwal C. Oral grape seed extract inhibits prostate tumor growth and progression in TRAMP mice. Cancer Research, 67; 5976-82, 2007.*share first co-author.[PMID: 17575168]
  48. Gu M, Singh RP, Dhanalakshmi S, Agarwal C, Agarwal R. Silibinin inhibits inflammatory and angiogenic attributes in photocarcinogenesis in SKH-1 hairless mice. Cancer Research, 67; 3483-91, 2007.[PMID: 17409458]
  49. Singh RP, Agarwal R. Inducible nitric oxide synthase-vascular endothelial growth factor axis: a potential target to inhibit tumor angiogenesis by dietary agents. Current Cancer Drug Targets, 7; 475-83, 2007.[PMID: 17691907]
  50. Singh RP, Agarwal R. Mechanisms of action of novel agents for prostate cancer chemoprevention. Endocrine-related Cancer, 13; 751-78, 2006.[PMID: 16954429]
  51. Singh RP, Agarwal R. Prostate cancer chemoprevention by silibinin: From bench to bed side. Molecular Carcinogenesis, 45; 436-42, 2006.[PMID: 16637061]
  52. Agarwal R, Agarwal C, Ichikawa H, Singh RP, Aggarwal BB. Anticancer potential of silymarin: From bench to bedside. Anticancer Research, 26(6B); 4457-98, 2006.[PMID: 17201169]
  53. Kaur M*, Singh RP*, Gu M, Agarwal R, Agarwal C.Grape seed extract inhibits in vitro and in vivo growth of human colorectal carcinoma cells. Clinical Cancer Research, 12; 6194-202, 2006. *share first co-author.[PMID: 17062697]

    This article was selected for the ‘Highlights’ section of the journal issue.

  54. Singh RP, Deep G, Chittezhath M, Kaur M, Dwyer-Nield LD, Malkinson AM, Agarwal R. Effect of silibinin on the growth and progression of primary lung tumors in mice. Journal of National Cancer Institute, 98; 846-55, 2006.[PMID: 16788158]
  55. In Brief, Silibinin and lung tumor growth and progression. JNCI, 98; 799, 2006.
  56. Mallikarjuna GU, Singh RP, Dhanalakshmi S, Mohan S, Agarwal R. Differential Effects of silibinin on E2Fs and associated biological events in chronically ultraviolet B-exposed skin versus tumors in SKH1 hairless mice. Molecular Cancer Therapeutics,5; 2121-29,2006.[PMID: 16928834]
  57. Singh RPAgarwal R.Natural flavonoids targeting deregulated cell cycle progression in cancer cells. Cancer Drug Targets, 7; 345-54, 2006.[PMID: 16515531]
  58. Tyagi A, Singh RP, Agarwal C, Agarwal R. Silibinin activates p53-caspase-2 pathway and causes caspase-mediated cleavage of cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: an evidence for a regulatory loop between p53 and caspase-2. Carcinogenesis, 27; 2269-80, 2006.[PMID: 16777994]
  59. Singh RP, Dhanalakshmi S, Mohan S, Agarwal C, Agarwal R. Silibinin inhibits UVB- and EGF-induced mitogenic and cell survival signaling involving AP-1 and NF-kappa B in mouse epidermal JB6 cells. Molecular Cancer Therapeutics,5; 1145-53,2006.[PMID: 16731746]
  60. Veluri R, Singh RP, Liu Z, Thompson JA, Agarwal R, Agarwal C. Fractionation of grape seed extract and identification of gallic acid as one of the major active constituents causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells. Carcinogenesis, 27; 1445-53, 2006.[PMID: 16474170]
  61. Deep G, Singh RP, Agarwal C, Kroll DJ, Agarwal R. Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin. Oncogene, 25; 1053-69, 2006.[PMID: 16205633]
  62. Singh RP, Banerjee S, Kumar PV, Raveesha KA, Rao AR. Tinospora cordifolia induces enzymes of carcinogen/drug metabolism and antioxidant system, and inhibits lipid peroxidation in mice. Phytomedicine,1-2; 74-84, 2006.[PMID: 16360936]
  63. Varghese L, Agarwal C, Tyagi A, Singh RP, Agarwal R. Silibinin efficacy against human hepatocellular carcinoma. Clinical Cancer Research, 11; 8841-48, 2005.[PMID: 16322307]
  64. Tyagi A, Singh RP, Agarwal C, Siriwardana S, Sclafani RA, Agarwal R. Resveratrol causes Cdc2-tyr15 phosphorylation via ATM/ATR-Chk1/2-Cdc25C pathway as a central mechanism for S phase arrest in human ovarian carcinoma Ovcar-3 cells. Carcinogenesis, 26; 1978-87, 2005.[PMID: 15975956]
  65. Gu M, Dhanalakshmi S, Singh RP, Agarwal R. Silibinin inhibits ultraviolet B radiation-induced mitogenic and survival signaling, and associated biological responses in SKH-1 mouse skin. Carcinogenesis, 26: 1404-13, 2005.[PMID: 15831527]
  66. Dhanalakshmi S, Agarwal C, Singh RP, Agarwal R. Silibinin up-regulates DNA-PK-dependent p53 activation to enhance UVB-induced apoptosis in mouse epithelial JB6 cells. Journal of Biological Chemistry, 280: 20375-83, 2005.[PMID: 15792956]
  67. Gu M, Dhanalakshmi S, Singh RP, Agarwal R. Dietary feeding of silibinin prevents early biomarkers of ultraviolet B radiation-induced carcinogenesis in SKH-1 hairless mouse epidermis. Cancer Epidemiology Biomarkers and Prevention, 14: 1344-9, 2005.[PMID: 15894701]
  68. Singh RP, Agrawal P, Yim D, Agarwal C, Agarwal R. Acacetin inhibits cell growth and cell cycle progression, and induces apoptosis in human prostate cancer cells: structure-activity relationship with linarin and linarin acetate. Carcinogenesis, 26: 845-54, 2005.[PMID: 15637089]
  69. Padmavathi B, Upreti M, Singh V, Rao AR, Singh RP, Rath PC. Chemoprevention by Hippophae rhamnoides: effects on tumorigenesis, phase II and antioxidant enzymes and IRF-1 transcription factor. Nutrition and Cancer, 51: 59-67, 2005.[PMID: 15749631]
  70. Padmavathi B, Rath PC, Rao AR, Singh RP. Roots of Withania somnifera inhibit forestomach and skin carcinogenesis in mice. Evidenced-based Alternative and Complementary Medicine, 2: 99-105, 2005.[PMID: 15841284]
  71. Yim D, Singh RP, Agarwal C, Lee S, Chi H, Agarwal R. A novel anticancer agent, decursin, induces G1 arrest and apoptosis in human prostate carcinoma DU145 cells. Cancer Research, 65: 1035-44, 2005.[PMID: 15705905]
  72. Singh RP, Dhanalakshmi S, Agarwal C, Agarwal R. Silibinin strongly inhibits growth and survival of endothelial cells via cell cycle arrest and down-regulation of survivin, Akt and NF-kappa B: implications for angioprevention and antiangiogenic therapy. Oncogene, 24: 1188-202, 2005.[PMID: 15558015]
  73. Kaur M, Agarwal C, Singh RP, Guan X, Dwivedi C, Agarwal R. Skin cancer chemopreventive agent, alpha-santalol, induces apoptotic death of human epidermoid carcinoma A431 cells via caspases activation together with dissipation of mitochondrial membrane potential and cytochrome c release. Carcinogenesis, 26: 369-80, 2005.[PMID: 15528219]
  74. Singh RP, Agarwal R. Mechanisms and preclinical efficacy of silibinin in preventing skin cancer. European Journal of Cancer, 41: 1969-79, 2005.[PMID: 16084079]
  75. Singh RP, Agarwal R. Inositol hexaphosphate and prostate cancer: efficacy and mechanisms. Anticancer Research, 25: 2891-903, 2005. [PMID: 16080543]
  76. Agarwal C, Dhanalakshmi S, Singh RP, Agarwal R. Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of androgen-dependent human prostate carcinoma LNCaP cells. Neoplasia, 6: 646-59, 2004.[PMID: 15548374]
  77. Singh RP, Mallikarjuna GU, Sharma G, Dhanalakshmi S, Tyagi AK, Chan DC, Agarwal C, Agarwal R. Oral silibinin inhibits lung tumor growth in athymic nude mice and forms a novel chemo-combination with doxorubicin targeting NF-kappa B-mediated inducible chemoresistance. Clinical Cancer Research, 10: 8641-7, 2004.[PMID: 15623648]
  78. Mallikarjuna G, Dhanalakshmi S, Singh RP, Agarwal C, Agarwal R. Silibinin protects from photocarcinogenesis via modulation of cell cycle regulators, and mitogen-activated protein kinases and Akt signaling. Cancer Research, 64: 6349-56, 2004.[PMID: 15342425]
  79. Mohan S, Dhanalakshmi S, Mallikarjuna GU, Singh RP, Agarwal R. Silibinin modulates UVB-induced apoptosis via mitochondrial proteins, caspases activation and mitogen-activated protein kinase signaling in human epidermoid carcinoma A431 cells. Biochemical Biophysical Research Communications, 320: 183-9, 2004.[PMID: 15207719]
  80. Singh RP, Agarwal R. Prostate cancer prevention by silibinin. Current Cancer Drug Target, 4: 1-11, 2004.[PMID: 14965263]
  81. Singh RP, Agarwal R. A cancer chemopreventive agent silibinin, targets mitogenic and cell survival signaling in prostate cancer. Mutation Research, 555: 21-32, 2004.[PMID: 15476849]
  82. Dhanalakshmi S, Mallikarjuna GU, Singh RP, Agarwal R. Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 in epidermis. Carcinogenesis, 25: 1459-65, 2004.[PMID: 15033902]
  83. Sharma G, Tyagi AK, Singh RP, Chan DC, Agarwal R. Synergistic anticancer effects of grape seed extract and conventional cytotoxic agent doxorubicin against human breast carcinoma cells. Breast Cancer Research and Treatment,85; 1-12, 2004.[PMID: 15039593]
  84. Singh RP, Sharma G, Mallikarjuna GU, Dhanalakshmi S, Agarwal C, Agarwal R. In vivo suppression of hormone-refractory prostate cancer growth by inositol hexaphosphate: induction of insulin-like growth factor binding protein-3 and inhibition of vascular endothelial growth factor. Clinical Cancer Research,10, 244-50, 2004.[PMID: 14734476]
  85. Agarwal C, Singh RP, Dhanalakshmi S, Agarwal R. Antiangiogenic efficacy of grape seed extract in endothelial cells. Oncology Reports, 11: 681-685, 2004.[PMID: 14767522]
  86. Singh RP, Tyagi AK, Dhanalakshmi S, Agarwal R, Agarwal C. Grape seed extract inhibits advanced human prostate tumor growth and angiogenesis and upregulates insulin-like growth factor binding protein-3. International Journal of Cancer,108: 733-40, 2004.[PMID: 14696100]
  87. Dhanalakshmi S, Mallikarjuna GU, Singh RP, Agarwal R. Dual-efficacy of silibinin in protecting or enhancing ultraviolet B radiation-caused apoptosis in human immortalized keratinocyte HaCaT cells. Carcinogenesis,25: 99-106, 2004.[PMID: 14555614]
  88. Agarwal C, Singh RP, Dhanalakshmi S, Tyagi AK, Tecklenburg M, Sclafani RA, Agarwal R. Silibinin up-regulates the expression of cyclin-dependent kinase inhibitors, and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells. Oncogene, 22: 8271-82, 2003.[PMID: 14614451]
  89. Tyagi AK, Agarwal C, Singh RP, Shroyer KR, Glode LM, Agarwal R.  Silibinin down-regulates survivin protein and mRNA expression and causes caspases activation and apoptosis in human bladder transitional-cell papilloma RT4 cells. Biochemical Biophysical Research Communications, 312: 1178-84, 2003.[PMID: 14651997]
  90. Agarwal C, Dhanalakshmi S, Singh RP, Agarwal R. Inositol hexaphosphate inhibits constitutive activation of NF- kappa B in androgen-independent human prostate carcinoma DU145 cells. Anticancer Research, 23: 3855-61, 2003.[PMID: 14666688]
  91. Qi L, Singh RP, Lu Y, Agarwal R, Harrison GS, Franzusoff A, Glode LM.  Epidermal growth factor receptor mediates silibinin-induced cytotoxicity in a rat glioma cell line. Cancer Biology and Therapy, 2: 526-31, 2003.[PMID: 14614320]
  92. This article was selected for the “commentary” by the journal: Jonathan A. F. Hannay and Dihua Yu. Silibinin, a thorny therapeutic for EGFR expressing tumors. Cancer Biology and Therapy, 2: 532-33, 2003.[PMID: 14614321]
  93. Singh RP, Sharma G, Dhanalakshmi S, Agarwal C, Agarwal R. Suppression of advanced human prostate tumor growth in athymic mice by silibinin feeding is associated with reduced cell proliferation, increased apoptosis and inhibition of angiogenesis. Cancer Epidemiology Biomarkers and Prevention, 12: 933-9, 2003[PMID: 14504208]
  94. Sharma G, Singh RP, Agarwal R. Growth inhibitory and apoptotic effects of inositol hexaphosphate in transgenic adenocarcinoma of mouse prostate (TRAMP-C1) cells. International Journal of Oncology, 23: 1413-8, 2003.[PMID: 14532984]
  95. Sharma G, Singh RP, Chan DC, Agarwal R. Silibinin induces growth inhibition and apoptotic cell death in human lung carcinoma cells. Anticancer Research, 23: 2649-56, 2003.[PMID: 12894553]
  96. Singh RP, Agarwal C, Agarwal R. Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells: modulation of CDKI-CDK-cyclin and pRb-related protein-E2F complexes. Carcinogenesis, 24: 555-63, 2003[PMID: 12663518]
  97. Singh RP, Agarwal R. Tumor angiogenesis: a potential target in cancer control by phytochemicals. Current Cancer Drug Target, 3: 205-17, 2003. [PMID: 12769689]
  98. Agarwal C, Singh RP, Agarwal R. Grape seed extract inhibits growth and induces apoptotic death of prostate carcinoma DU145 cells via caspases activation, accompanied by dissipation of mitochondrial membrane potential and cytochrome c release. Carcinogenesis,23:1869-76, 2002[PMID: 12419835]
  99. Singh RP, Agarwal R. Flavonoid antioxidant silymarin and skin cancer. Antioxidant and Redox Signaling, 4: 655-63, 2002.[PMID: 12230878]
  100. Singh RP, Dhanalakshmi S, Agarwal R. Phytochemicals as cell cycle modulators: a less toxic approach in halting human cancers. Cell Cycle, 1: 156-61, 2002. [PMID: 12429925]
  101. Tyagi AK, Singh RP, Agarwal C, Chan DC, Agarwal R. Silibinin strongly synergizes human prostate carcinoma DU145 cells to doxorubicin-induced growth inhibition, G2-M arrest and apoptosis. Clinical Cancer Research, 8: 3512-19, 2002.[PMID: 12429642]
  102. This article was selected for the “commentary” by the journal: Robert S. DiPaola. To arrest or not to G2-M cell-cycle arrest. Clinical Cancer Research, 8: 3311-4, 2002.[PMID: 12429616]
  103. Singh RP, Dhanalakshmi S, Tyagi AK, Chan DC, Agarwal C, Agarwal R.  Dietary feeding of silibinin inhibits advance human prostate carcinoma growth in athymic nude mice, and increases plasma insulin-like growth factor-binding protein-3 levels. Cancer Research, 62: 3063-9, 2002.[PMID: 12036915]
  104. Singh RP, Tyagi AK, Zhao J, Agarwal R. Silymarin inhibits growth and causes regression of established skin tumors in SENCAR mice via modulation of mitogen-activated protein kinases and induction of apoptosis. Carcinogenesis, 23: 499-510, 2002.[PMID: 11895866]
  105. Dhanalakshmi S, Singh RP, Agarwal C, Agarwal R. Silibinin inhibits constitutive and TNF-alpha-induced activation of NF-kappa B and sensitizes human prostate carcinoma DU145 cells to TNFa-induced apoptosis. Oncogene, 21: 1759-67, 2002.[PMID: 11896607]
  106. Singh RP, Banerjee S, Rao AR. Modulatory influence of Andrographis paniculata on mouse hepatic and extrahepatic carcinogen metabolizing enzymes and antioxidant status. Phytotherapy Research,15: 382-90, 2001.[PMID: 11507728]
  107. Zi X, Singh RP, Agarwal R. Impairment of erbB1 receptor and fluid-phase endocytosis, and associated mitogenic signaling by inositol hexaphosphate in human prostate carcinoma DU145 cells. Carcinogenesis, 21: 2225-35, 2000.[PMID: 11133812]
  108. Singh RP, Padmavathi B, Rao AR. Chemomodulatory influence of Adhatoda vesica (Justicia adhatoda) on the enzymes of xenobiotic metabolism, antioxidant status and lipid peroxidation in mice. Molecular and Cellular Biochemistry, 213: 99-109, 2000[PMID: 11129964]
  109. Singh RP, Banerjee S, Rao AR. Effect of Aegle marmelos on biotransformation enzymes system and protection against free radicals mediated damage in mice. Journal of Pharmacy and Pharmacology, 52: 991-1000, 2000.[PMID: 11007071]
  110. Singh RP, Dhanalakshmi S, Rao AR. Chemomodulatory action of Aloe vera on the profiles of enzymes associated with carcinogen metabolism and antioxidant status regulation in mice. Phytomedicine, 7: 209-19, 2000[PMID: 11185732]


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