Prof. Rana P. Singh is a leading cancer biologist whose research spans molecular oncology, chemoprevention, photodynamic therapy, and mitochondrial biology. His work has been widely cited in high-impact journals such as Molecular Cancer Therapeutics, Mitochondrion, Phytomedicine, Biochemical and Biophysical Research Communications, and PLOS ONE. A major focus of his research involves understanding the mechanisms of apoptosis, mitochondrial dysfunction, and cellular stress responses in cancer cells, particularly in the context of natural compounds and targeted therapeutics. Notably, his studies on the anti-cancer potential of phytochemicals and synthetic analogs have gained recognition, including highly cited papers on mitochondrial-mediated apoptosis published in Chemico-Biological Interactions and Molecular and Cellular Biochemistry. Prof. Singh’s interdisciplinary approach combines biochemical assays, cell signaling analysis, and animal models to explore novel therapeutic strategies, contributing significantly to translational cancer research.
Updated till March 2025*
2025-03-14
AXL signaling in cancer: from molecular insights to targeted therapies
Type: Scholarly article
Published in: Signal Transduction and Targeted Therapy
Authors: SMonika Yadav, Akansha Sharma, Ketki Patne, Saba Tabasum, Jyoti Suryavanshi, Laxminarayan Rawat, Marc Machaalani, Marc Eid, Rana P. Singh, Toni K. Choueiri, Soumitro Pal & Akash Sabarwal
2025-02-10
Chemical composition, antioxidant, antimicrobial, and anticancer activities of Mahonia napaulensis DC. bark from Nepal
Type: Scholarly article
Published in: BMC Complementary Medicine and Therapies
Authors: Rajib Kumar Shrestha, Satyabrata Nayak, Prabal Singh Maharjan, Bivek Pokharel, Gagan Deep Jhingan, Rana Pratap Singh, Neel Sarovar Bhavesh & Bhupal Govinda Shrestha
2024-11-05
Linking COVID-19 and cancer: Underlying mechanism
Type: Scholarly article
Published in: Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease
Authors: Sourabh Tyagi, Nipanshi Tyagi, Anu Singh, Akanksha Gautam, Awantika Singh, Shelja Jindal, Rana P Singh, Rupesh Chaturvedi, Hemant Ritturaj Kushwaha
2024-10-14
Polydatin inhibits histone deacetylase 1 and shows an anti-angiogenic action in head and neck squamous cell carcinoma
Type: Scholarly article
Published in: Medical Oncology
Authors: Aadil Manzoor Baba, Altaf Ahmad Shah, Imren Bayil, Satyabrata Nayak, Ritis Kumar Shyanti, Najma Nissa, Mansha Muzaffar, Mohammad Amin Hajam, Rezwan Akhtar, Bashir Ahmad Malla, Salman Akhtar, Rana P Singh, Nazir Ahmad Dar
2024-10-01
Cancer Pathways Targeted by Berberine: Role of microRNAs
Type: Scholarly article
Published in: Current Medicinal Chemistry
Authors: Mansoor Ali, Deepali Mishra, Rana P Singh
2024-09-26
Oncogenic potential of SARS-CoV-2—targeting hallmarks of cancer pathways
Type: Scholarly article
Published in: Cell Communication and Signaling
Authors: Aishwarya Jaiswal, Sanah Shrivastav, Hemant R Kushwaha, Rupesh Chaturvedi, Rana P Singh
2024-07-21
Decursin Inhibits Expression and Nuclear Localization of DNMT and HDAC, and Suppresses the Growth and Survival of Prostate Cancer Cells
Type: Scholarly article
Published in: Asian Pacific Journal of Cancer Biology
Authors: Lalita Dwivedi, Aishwarya Jaiswal, Reenu Punia, R Suresh Kumar, Dongsool Yim, Paulraj Rajamani, Rana P Singh
2024-05-27
Fisetin induces G2/M phase arrest and caspase‐mediated cleavage of p21Cip1 and p27Kip1 leading to apoptosis and tumor growth inhibition in HNSCC
Type: Scholarly article
Published in: Molecular Carcinogenesis
Authors: Monika Yadav, Kushal Kandhari, Sivapar V Mathan, Mansoor Ali, Rana P Singh
2024-05-01
Silymarin prevents endothelial dysfunction by upregulating Erk-5 in oxidized LDL exposed endothelial cells
Type: Scholarly article
Published in: Microvascular Research
Authors: Rohit Patel, Sanjay Kumar, Johnna F Varghese, Navneendra Singh, Rana P Singh, Umesh CS Yadav
2024-03-01
Simulated microgravity induces DNA damage concurrent with impairment of DNA repair and activation of cell-type specific DNA damage response in microglial and glioblastoma cells
Type: Scholarly article
Published in: Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
Authors: Ragini Singh, Aishwarya Jaiswal, Rana P Singh
2024
Mechanism of synergistic inhibitory effect of benzyl isothiocyanate and zoledronic acid combination on breast cancer induction of osteoclast differentiation
Type: Scholarly article
Published in: Molecular Carcinogenesis
Authors: Eun-Ryeong Hahm, Su-Hyeong Kim, Subrata K Pore, Sivapar V Mathan, Rana P Singh, Shivendra V Singh
2024-01-16
Diallyl Trisulfide Induces ROS-Mediated Mitotic Arrest and Apoptosis and Inhibits HNSCC Tumor Growth and Cancer Stemness
Type: Scholarly article
Published in: Cancers
Authors: Sivapar V Mathan, Ragini Singh, Su-Hyeong Kim, Shivendra V Singh, Rana P Singh
2024-01-05
Thespesia lampas mediated green synthesis of silver and gold nanoparticles for enhanced biological applications
Type: Scholarly article
Published in: Frontiers in Microbiology
Authors: Sunayana Nath, Ritis Kumar Shyanti, Rana P Singh, Manoj K Mishra, Bhawana Pathak
2024-01-04
4'-substituted analogues of fisetin and their use in the treatment of cancer
Type: Scholarly article
Authors: Catherine Hart Kaschula, Rana Pratap Singh, Arpit Dheeraj, Akash Sabarwal
2024
Clonal spheroids capture functional and genetic heterogeneity of head and neck cancer
Type: Scholarly article
Published in: bioRxiv
Authors: Jyoti Pandey, Md Zubbair Malik, Ritis K Shyanti, Palak Parashar, Praveen K Kujur, Deepali Mishra, Dhanir Tailor, Jee Min Lee, Tejinder Kataria, Deepak Gupta, Hitesh Verma, Sanjay V Malhotra, Suneel Kateriya, Vibha Tandon, Rupesh Chaturvedi, Rana P Singh
2023-09-1
Invasive Breast Cancer: miR-24-2 Targets Genes Associated with Survival and Sensitizes MDA-MB-231 Cells to Berberine
Type: Scholarly article
Published in: OMICS: A Journal of Integrative Biology
Authors: Mansoor Ali, Rameshwar NK Bamezai, Rana P Singh
2023-06-25
Targeting DNA repair for cancer treatment: Lessons from PARP inhibitor trials
Type: Scholarly article
Published in: Oncology Research
Authors: DHANAY K NAMBIAR, DEEPALI MISHRA, RANA P. SINGH
2023-01-03
Decursin inhibits EGFR-ERK1/2 signaling axis in advanced human prostate carcinoma cells
Type: Scholarly article
Published in: The Prostate
Authors: Tariq A Bhat, Arpit Dheeraj, Dhanya K Nambiar, Surya Pratap Singh, Dong Sool Yim, Rana P Singh
2023-04-04
Single cell-derived spheroids capture functional and genetic heterogeneity of head and neck cancer
Type: Scholarly article
Published in: Cancer Research
Authors: Jyoti Pandey, Md Jubbair Malik, Ritis K Shyanti, Jee Min Lee, Dhanir Tailor, Sanjay V Malhotra, Rupesh Chaturvedi, Rana P Singh
2023-03-01
Acacetin induces sustained ERK1/2 activation and RIP1-dependent necroptotic death in breast cancer cells
Type: Scholarly article
Published in: Toxicology and Applied Pharmacology
Authors: Kushal Kandhari, Jai PN Mishra, Rajesh Agarwal, Rana P Singh
2023
A Polyherbal Formulation Habb-e-Ustukhuddus Induces Apoptosis and Inhibits Cell Migration in Lung and Breast Cancer Cells without Any Toxicity in Mice
Type: Cancer biology
Published in: Asian Pacific Journal of Cancer Prevention: APJCP
Authors: Reenu Punia, Mansoor Ali, Yasmeen Shamsi, Rana P Singh
2022-11-24
A novel 4′-brominated derivative of fisetin induces cell cycle arrest and apoptosis and inhibits EGFR/ERK1/2/STAT3 pathways in non-small-cell lung cancer without any adverse effects in mice
Type: Scholarly article
Published in: The FASEB Journal
Authors: Akash Sabarwal, Jaco C van Rooyen, Jeremy Caburet, Moscos Avgenikos, Arpit Dheeraj, Mansoor Ali, Deepali Mishra, Joséphine SB de Meester, Saskia Stander, Willem AL van Otterlo, Catherine H Kaschula, Rana P Singh
2022-11-08
Determination of antioxidant potential of Salix aegyptiaca L. through biochemical analysis
Type: Scholarly article
Published in: Indian Journal of Experimental Biology (IJEB)
Authors: Mohd Nauman, RK Kale, Preeti Dhruve, Rana P Singh
2022-05-30
Bioengineered and biocompatible silver nanoparticles from Thalictrum foliolosum DC and their biomedical applications
Type: Scholarly article
Published in: Clean Technologies and Environmental Policy
Authors: Sandip Kumar Chandraker, Mishri Lal, Preeti Dhruve, Amit Kumar Yadav, Rana P Singh, Rajender S Varma, Ravindra Shukla
2022-09-30
Silibinin Radiosensitizes EGF Receptor-knockdown Prostate Cancer Cells by Attenuating DNA Repair Pathways
Type: Scholarly article
Published in: Journal of Cancer Prevention
Authors: Mohit Rajput, Deepali Mishra, Kunal Kumar, Rana P Singh
2022-07-01
Physicochemical Properties of Silibinin-Phosphatidylcholine Complex and its Implications for Drug Formulations.
Type: Scholarly article
Published in: Indian Journal of Pharmaceutical Sciences
Authors: Reenu Punia, C Singh, RP Singh, M Singh
2022-06-15
Development of single cell spheroid as a tool to capture functional heterogeneity in head and neck cancer
Type: Scholarly article
Published in: Cancer Research
Authors: Jyoti Pandey, Ritis Shyanti, Sanjay V Malhotra, Rupesh Chaturvedi, Rana P Singh
2022-06-06
Breast Cancer Selective Disruption of Actin Cytoskeleton by Diallyl Trisulfide
Type: Scholarly article
Published in: Journal of Cancer Prevention
Authors: Eun-Ryeong Hahm, Sivapar V Mathan, Rana P Singh, Shivendra V Singh
2022-05-25
Therapeutic potential of biogenic and optimized silver nanoparticles using Rubia cordifolia L. leaf extract
Type: Scholarly article
Published in: Scientific Reports
Authors: Sandip Kumar Chandraker, Mishri Lal, Farheen Khanam, Preeti Dhruve, Rana P Singh, Ravindra Shukla
2022-03-04
A novel hepatoprotective activity of Alangium salviifolium in mouse model
Type: Scholarly article
Published in: Drug and Chemical Toxicology
Authors: Preeti Dhruve, Mohd Nauman, Raosaheb K Kale, Rana P Singh
2022-01-19
Study of Rotary Cell Culture System-Induced Microgravity Effects on Cancer Biomarkers
Type: Book
Published in: Cancer Biomarkers: Methods and Protocols
Authors: Ragini Singh, Rana P Singh
2022-06-25
Green Synthesis of Silver Nanoparticles Using the Tridax procumbens Plant Extract and Screening of Its Antimicrobial and Anticancer Activities
Type: Research Article
Published in: Oxidative Medicine and Cellular Longevity
Authors: Rohini Pungle, Shivraj Hariram Nile, Nilesh Makwana, Ragini Singh, Rana P Singh, Arun S Kharat
2022-01-01
Chemotherapy and radiation therapy for cancer
Type: Book
Published in: Understanding Cancer
Authors: Sivapar V Mathan, Mohit Rajput, Rana P Singh
2021-12-01
EGFR-mediated Rad51 expression potentiates intrinsic resistance in prostate cancer via EMT and DNA repair pathways
Type: Scholarly article
Published in: Life Sciences
Authors: Mohit Rajput, Ragini Singh, Navneendra Singh, Rana P Singh
2021-11-01
Simulated microgravity triggers DNA damage and mitochondria-mediated apoptosis through ROS generation in human promyelocytic leukemic cells
Type: Scholarly article
Published in: Mitochondrion
Authors: Ragini Singh, Mohit Rajput, Rana P Singh
2021-08-17
Current insights and advancements in head and neck Cancer: emerging biomarkers and therapeutics with cues from single cell and 3D model omics profiling
Type: Scholarly article
Published in: Frontiers in Oncology
Authors: Yashika Jawa, Pooja Yadav, Shruti Gupta, Sivapar V Mathan, Jyoti Pandey, Ajay K Saxena, Suneel Kateriya, Ashu B Tiku, Neelima Mondal, Jaydeep Bhattacharya, Shandar Ahmad, Rupesh Chaturvedi, Rakesh K Tyagi, Vibha Tandon, Rana P Singh
2021-06-30
Effects of garlic compound diallyl trisulfide on head and neck cancer cells and cancer stem cells in vitro and in vivo
Type: Scholarly article
Published in: Cancer Research
Authors: Sivapar V. Mathan; Su-Hyeong Kim; Shivendra V. Singh; Rana P. Singh
2021-06-30
Mechanistic Targets of Diallyl Trisulfide in Human Breast Cancer Cells Identified by RNA-seq Analysis
Type: Scholarly article
Published in: Journal of Cancer Prevention
Authors: Eun-Ryeong Hahm, Su-Hyeong Kim, Sivapar V Mathan, Rana P Singh, Shivendra V Singh
2021-04-14
Integrated analysis and identification of nine-gene signature associated to oral squamous cell carcinoma pathogenesis
Type: Scholarly article
Published in: 3 Biotech
Authors: Monika Yadav, Dibyabhaba Pradhan & Rana P. Singh
2021-04-14
Integrated analysis and identification of nine-gene signature associated to oral squamous cell carcinoma pathogenesis
Type: Scholarly Article
Published in: 3 Biotech
Author: Rana P. Singh
2019-03-25
Berberine enhances posttranslational protein stability of p21/cip1 in breast cancer cells via down-regulation of Akt
Type: Scholarly Article
Published in: Molecular and Cellular Biochemistry
Author: Rana P. Singh
2019-02-22
Fisetin suppresses migration, invasion and stem-cell-like phenotype of human non-small cell lung carcinoma cells via attenuation of epithelial to mesenchymal transition
Type: Scholarly Article
Published in: Chemico-biological Interactions
Author: Rana P. Singh
2018-09-01
Hazardous effects of chemical pesticides on human health-Cancer and other associated disorders
Type: Scholarly Article
Published in: Environmental Toxicology and Pharmacology
Authors: Kunal Kumar, Rana P. Singh
2018-06-11
Mancozeb selectively induces mitochondrial-mediated apoptosis in human gastric carcinoma cells through ROS generation
Type: Scholarly Article
Published in: Mitochondrion
Author: Rana P. Singh
2018-03-22
Integrin expression and glycosylation patterns regulate cell-matrix adhesion and alter with breast cancer progression
Type: Scholarly Article
Published in: Biochemical and Biophysical Research Communications
Author: Rana P. Singh
2018-03-07
Polyphenols of Salix aegyptiaca modulate the activities of drug metabolizing and antioxidant enzymes, and level of lipid peroxidation
Type: Scholarly Article
Published in: BMC Complementary and Alternative Medicine
Author: Rana P. Singh
2017-10-19
Flavonoids inhibit chronically exposed arsenic-induced proliferation and malignant transformation of HaCaT cells
Type: Scholarly Article
Published in: Photodermatology, Photoimmunology and Photomedicine
Author: Rana P. Singh
2017-08-31
Acacetin enhances the therapeutic efficacy of doxorubicin in non-small-cell lung carcinoma cells
Type: Scholarly Article
Published in: PLOS One
Author: Rana P. Singh
2016-07-08
A novel alkaloid, evodiamine causes nuclear localization of cytochrome-c and induces apoptosis independent of p53 in human lung cancer cells
Type: Scholarly Article
Published in: Biochemical and Biophysical Research Communications
Author: Rana P. Singh
2016-01-01
Angiogenesis Assays
Type: Scholarly Article
Published in: Methods in Molecular Biology
Author: Rana P. Singh
2015-10-29
Silibinin Preferentially Radiosensitizes Prostate Cancer by Inhibiting DNA Repair Signaling
Type: Scholarly Article
Published in: Molecular Cancer Therapeutics
Authors: Gagan Deep, Rajesh Agarwal, Rana P. Singh
2015-04-14
Silibinin combination with arsenic strongly inhibits survival and invasiveness of human prostate carcinoma cells
Type: Scholarly Article
Published in: Nutrition and Cancer
Author: Rana P. Singh
2014-11-24
Silibinin attenuates ionizing radiation-induced pro-angiogenic response and EMT in prostate cancer cells
Type: Scholarly Article
Published in: Biochemical and Biophysical Research Communications
Author: Rana P. Singh
2014-05-01
Mitochondria in health and disease
Type: Editorial, Scholarly Article
Published in: Mitochondrion
Authors: Rana P. Singh, Kumarasamy Thangaraj
2014-05-01
Microgravity alters cancer growth and progression
Type: Scholarly Article
Published in: Current Cancer Drug Targets
Authors: Dhwani Jhala, Rana P. Singh
2014-02-18
The TAF9 C-terminal conserved region domain is required for SAGA and TFIID promoter occupancy to promote transcriptional activation.
Type: Scholarly Article
Published in: Molecular and Cellular Biology
Author: Rana P. Singh
2013-10-28
Berberine in combination with doxorubicin suppresses growth of murine melanoma B16F10 cells in culture and xenograft
Type: Scholarly Article
Published in: Phytomedicine
Author: Rana P. Singh
2013-10-25
β-Sitosterol induces G1 arrest and causes depolarization of mitochondrial membrane potential in breast carcinoma MDA-MB-231 cells
Type: Scholarly Article
Published in: BMC Complementary and Alternative Medicine
Author: Rana P. Singh
2013-08-13
Acacetin inhibits in vitro and in vivo angiogenesis and downregulates Stat signaling and VEGF expression
Type: Scholarly Article
Published in: Cancer Prevention Research
Author: Rana P. Singh
2013-01-01
Advances in prostate cancer chemoprevention: a translational perspective.
Type: Scholarly Article
Published in: Nutrition and Cancer
Author: Rana P. Singh
2013-01-01
Introduction to Special Issue on Molecular Basis for Cancer Prevention with Bioactive Food Components in Nutrition and Cancer--an International Journal
Type: Scholarly Article
Published in: Nutrition and Cancer
Author: Rana P. Singh
2012-09-26
In vitro and in vivo anticancer efficacy of silibinin against human pancreatic cancer BxPC-3 and PANC-1 cells
Type: Scholarly Article
Published in: Cancer Letters
Author: Rana P. Singh
2011-12-01
Fisetin inhibits various attributes of angiogenesis in vitro and in vivo--implications for angioprevention
Type: Scholarly Article
Published in: Carcinogenesis
Author: Rana P. Singh
2011-08-31
Silibinin modulates TNF-α and IFN-γ mediated signaling to regulate COX2 and iNOS expression in tumorigenic mouse lung epithelial LM2 cells
Type: Scholarly Article
Published in: Molecular Carcinogenesis
Author: Rana P. Singh
2011-08-05
Effects of phytochemicals on ionization radiation-mediated carcinogenesis and cancer therapy
Type: Scholarly Article
Published in: Mutation Research
Author: Rana P. Singh
2011-05-18
Cap2-HAP complex is a critical transcriptional regulator that has dual but contrasting roles in regulation of iron homeostasis in Candida albicans
Type: Scholarly Article
Published in: Journal of Biological Chemistry
Author: Rana P. Singh
2011-01-25
Grape seed extract upregulates p21 (Cip1) through redox-mediated activation of ERK1/2 and posttranscriptional regulation leading to cell cycle arrest in colon carcinoma HT29 cells.
Type: Scholarly Article
Published in: Molecular Carcinogenesis
Authors: Robert Sclafani, Rana P. Singh
2010-12-10
Silibinin prevents lung tumorigenesis in wild-type but not in iNOS-/- mice: potential of real-time micro-CT in lung cancer chemoprevention studies
Type: Scholarly Article
Published in: Clinical Cancer Research
Author: Rana P. Singh
2010-09-07
Inhibitory effect of silibinin against azoxymethane-induced colon tumorigenesis in A/J mice
Type: Scholarly Article
Published in: Clinical Cancer Research
Author: Rana P. Singh
2010-07-01
Dietary-feeding of grape seed extract prevents azoxymethane-induced colonic aberrant crypt foci formation in fischer 344 rats.
Type: Scholarly Article
Published in: Molecular Carcinogenesis
Author: Rana P. Singh
2010-05-01
Silibinin suppresses growth of human colorectal carcinoma SW480 cells in culture and xenograft through down-regulation of beta-catenin-dependent signaling.
Type: Scholarly Article
Published in: Neoplasia
Author: Rana P. Singh
2010-03-09
Chemoprevention of intestinal tumorigenesis in APCmin/+ mice by silibinin
Type: Scholarly Article
Published in: Cancer Research
Author: Rana P. Singh
2010-01-01
Dietary feeding of grape seed extract prevents intestinal tumorigenesis in APCmin/+ mice
Type: Scholarly Article
Published in: Neoplasia
Author: Rana P. Singh
2009-09-25
Silibinin suppresses spontaneous tumorigenesis in APC min/+ mouse model by modulating beta-catenin pathway
Type: Scholarly Article
Published in: Pharmaceutical Research
Author: Rana P. Singh
2009-09-01
Cosmeceuticals and silibinin
Type: Review Article, Scholarly Article
Published in: Clinics in Dermatology
Author: Rana P. Singh
2009-01-27
p21/Cip1 and p27/Kip1 Are essential molecular targets of inositol hexaphosphate for its antitumor efficacy against prostate cancer.
Type: Scholarly Article
Published in: Cancer Research
Author: Robert Sclafani, Rana P. Singh
2009-01-01
Growth inhibition and regression of lung tumors by silibinin: modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3.
Type: Scholarly Article
Published in: Cancer Prevention Research
Author: Rana P. Singh
2009-01-01
Anti-tumor activity of oxypeucedanin from Ostericum koreanum against human prostate carcinoma DU145 cells
Type: Scholarly Article
Published in: Acta Oncologica
Author: Rana P. Singh
2009-01-01
Silibinin suppresses growth of human prostate carcinoma PC-3 orthotopic xenograft via activation of extracellular signal-regulated kinase 1/2 and inhibition of signal transducers and activators of transcription signaling
Type: Scholarly Article
Published in: Clinical Cancer Research
Author: Gagan Deep, Rajesh Agarwal, Rana P. Singh
2008-12-01
Silibinin inhibits established prostate tumor growth, progression, invasion, and metastasis and suppresses tumor angiogenesis and epithelial-mesenchymal transition in transgenic adenocarcinoma of the mouse prostate model mice
Type: Scholarly Article
Published in: Clinical Cancer Research
Author: Rana P. Singh
2008-12-01
Isosilibinin inhibits advanced human prostate cancer growth in athymic nude mice: comparison with silymarin and silibinin.
Type: Scholarly Article
Published in: International Journal of Cancer
Author: Nicholas H. Oberlies, Rana P. Singh
2008-08-01
Stage-specific inhibitory effects and associated mechanisms of silibinin on tumor progression and metastasis in transgenic adenocarcinoma of the mouse prostate model
Type: Scholarly Article
Published in: Cancer Research
Author: Gagan Deep, Rajesh Agarwal, Rana P. Singh
2008-05-01
Chemopreventive efficacy of inositol hexaphosphate against prostate tumor growth and progression in TRAMP mice
Type: Scholarly Article
Published in: Clinical Cancer Research
Author: Rana P. Singh
2008-03-01
Silibinin inhibits colorectal cancer growth by inhibiting tumor cell proliferation and angiogenesis
Type: Scholarly Article
Published in: Cancer Research
Author: Rana P. Singh
2008-01-01
Oral silibinin inhibits in vivo human bladder tumor xenograft growth involving down-regulation of survivin
Type: Scholarly Article
Published in: Clinical Cancer Research
Author: Rana P. Singh
2007-12-01
Chemopreventive effects of silymarin and silibinin on N-butyl-N-(4-hydroxybutyl) nitrosamine induced urinary bladder carcinogenesis in male ICR mice
Type: Scholarly Article
Published in: Molecular Cancer Therapeutics
Author: Rana P. Singh
2007-11-01
Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model
Type: Scholarly Article
Published in: Cancer Research
Author: Rana P. Singh
2007-10-04
Silibinin suppresses in vivo growth of human prostate carcinoma PC-3 tumor xenograft
Type: Scholarly Article
Published in: Carcinogenesis
Author: Rana P. Singh
2007-08-29
Tumor angiogenesis--a potential target in cancer chemoprevention.
Type: Review Article, Scholarly Article
Published in: Food and Chemical Toxicology
Author: Rana P. Singh
2007-06-01
Oral grape seed extract inhibits prostate tumor growth and progression in TRAMP mice.
Type: Scholarly article
Published in: Cancer Research
Author: Rana P. Singh
2007-04-01
Silibinin inhibits inflammatory and angiogenic attributes in photocarcinogenesis in SKH-1 hairless mice.
Type: Scholarly article
Published in: Cancer Research
Author: Rana P. Singh
2006-10-01
Grape seed extract inhibits in vitro and in vivo growth of human colorectal carcinoma cells
Type: Scholarly article
Published in: Clinical Cancer Research
Author: Rana P. Singh
2006-09-01
Mechanisms of action of novel agents for prostate cancer chemoprevention.
Type: Review article, scholarly article
Published in: Endocrine-Related Cancer
Author: Rana P. Singh
2006-08-01
Differential effect of silibinin on E2F transcription factors and associated biological events in chronically UVB-exposed skin versus tumors in SKH-1 hairless mice.
Type: Scholarly article
Published in: Molecular Cancer Therapeutics
Author: Rana P. Singh
2006-06-15
Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2.
Type: Scholarly article
Published in: Carcinogenesis
Author: Rana P. Singh
2006-06-01
Effect of silibinin on the growth and progression of primary lung tumors in mice
Type: Scholarly article
Published in: Journal of the National Cancer Institute
Author: Rana P. Singh
2006-05-01
Silibinin inhibits UVB- and epidermal growth factor-induced mitogenic and cell survival signaling involving activator protein-1 and nuclear factor-kappaB in mouse epidermal JB6 cells.
Type: Scholarly article
Published in: Molecular Cancer Therapeutics
Author: Rana P. Singh
2006-03-01
Natural flavonoids targeting deregulated cell cycle progression in cancer cells.
Type: Review article, scholarly article
Published in: Current Drug Targets
Author: Rana P. Singh
2006-02-10
Fractionation of grape seed extract and identification of gallic acid as one of the major active constituents causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells
Type: Scholarly article
Published in: Carcinogenesis
Author: Rana P. Singh
2005-12-01
Silibinin efficacy against human hepatocellular carcinoma
Type: Scholarly Article
Published in: Clinical Cancer Research
Author: Rana P. Singh
2005-09-01
Mechanisms and preclinical efficacy of silibinin in preventing skin cancer.
Type: Review Article, Scholarly Article
Published in: European Journal of Cancer
Author: Rana P. Singh
2005-06-23
Resveratrol causes Cdc2-tyr15 phosphorylation via ATM/ATR-Chk1/2-Cdc25C pathway as a central mechanism for S phase arrest in human ovarian carcinoma Ovcar-3 cells
Type: Scholarly Article
Published in: Carcinogenesis
Author: Robert Sclafani, Rana P. Singh
2005-05-01
Dietary feeding of silibinin prevents early biomarkers of UVB radiation-induced carcinogenesis in SKH-1 hairless mouse epidermis
Type: Scholarly Article
Published in: Cancer Epidemiology, Biomarkers & Prevention
Author: Rana P. Singh
2005-04-14
Silibinin inhibits ultraviolet B radiation-induced mitogenic and survival signaling, and associated biological responses in SKH-1 mouse skin
Type: Scholarly Article
Published in: Carcinogenesis
Author: Rana P. Singh
2005-03-25
Silibinin up-regulates DNA-protein kinase-dependent p53 activation to enhance UVB-induced apoptosis in mouse epithelial JB6 cells
Type: Scholarly Article
Published in: Journal of Biological Chemistry
Author: Rana P. Singh
2005-02-01
Silibinin strongly inhibits growth and survival of human endothelial cells via cell cycle arrest and downregulation of survivin, Akt and NF-kappaB: implications for angioprevention and antiangiogenic therapy
Type: Scholarly Article
Published in: Oncogene
Author: Rana P. Singh
2005-01-06
Acacetin inhibits cell growth and cell cycle progression, and induces apoptosis in human prostate cancer cells: structure-activity relationship with linarin and linarin acetate
Type: Scholarly Article
Published in: Carcinogenesis
Author: Rana P. Singh
2004-12-01
Oral silibinin inhibits lung tumor growth in athymic nude mice and forms a novel chemocombination with doxorubicin targeting nuclear factor kappaB-mediated inducible chemoresistance
Type: Scholarly article
Published in: Clinical Cancer Research
Author: Rana P. Singh
2004-11-04
Skin cancer chemopreventive agent, {alpha}-santalol, induces apoptotic death of human epidermoid carcinoma A431 cells via caspase activation together with dissipation of mitochondrial membrane potential and cytochrome c release
Type: Scholarly article
Published in: Carcinogenesis
Author: Rana P. Singh
2004-09-01
Silibinin protects against photocarcinogenesis via modulation of cell cycle regulators, mitogen-activated protein kinases, and Akt signaling
Type: Scholarly article
Published in: Cancer Research
Author: Rana P. Singh
2004-07-01
Silibinin modulates UVB-induced apoptosis via mitochondrial proteins, caspases activation, and mitogen-activated protein kinase signaling in human epidermoid carcinoma A431 cells
Type: Scholarly article
Published in: Biochemical and Biophysical Research Communications
Author: Rana P. Singh
2004-05-01
Synergistic anti-cancer effects of grape seed extract and conventional cytotoxic agent doxorubicin against human breast carcinoma cells
Type: Scholarly article
Published in: Breast Cancer Research and Treatment
Author: Rana P. Singh
2004-03-19
Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 in epidermis
Type: Scholarly article
Published in: Carcinogenesis
Author: Rana P. Singh
2004-02-01
Grape seed extract inhibits advanced human prostate tumor growth and angiogenesis and upregulates insulin-like growth factor binding protein-3.
Type: Scholarly article
Published in: International Journal of Cancer
Author: Rana P. Singh
2004-01-01
In vivo suppression of hormone-refractory prostate cancer growth by inositol hexaphosphate: induction of insulin-like growth factor binding protein-3 and inhibition of vascular endothelial growth factor
Type: Scholarly article
Published in: Clinical Cancer Research
Author: Rana P. Singh
2003-12-01
Silibinin down-regulates survivin protein and mRNA expression and causes caspases activation and apoptosis in human bladder transitional-cell papilloma RT4 cells
Type: Scholarly article
Published in: Biochemical and Biophysical Research Communications
Author: Rana P. Singh
2003-11-01
Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells
Type: Scholarly article
Published in: Oncogene
Author: Robert Sclafani, Rana P. Singh
2003-10-10
Dual efficacy of silibinin in protecting or enhancing ultraviolet B radiation-caused apoptosis in HaCaT human immortalized keratinocytes
Type: Scholarly article
Published in: Carcinogenesis
Author: Rana P. Singh
2003-09-01
Epidermal growth factor receptor mediates silibinin-induced cytotoxicity in a rat glioma cell line
Type: Scholarly article
Published in: Cancer Biology and Therapy
Author: Rana P. Singh
2003-03-01
Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells: modulation of CDKI-CDK-cyclin and pRb-related protein-E2F complexes
Type: Scholarly article
Published in: Carcinogenesis
Author: Rana P. Singh
2001-08-01
Modulatory influence of Andrographis paniculata on mouse hepatic and extrahepatic carcinogen metabolizing enzymes and antioxidant status
Type: Scholarly article
Published in: Phytotherapy Research
Author: Rana P. Singh
